Any one obtaining illicit diazepam must be especially cautious of any which might be sold beneath the name “Accord” or “Actavis” or have the false batch range 831N176.

apalutamide will lessen the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with drugs which are CYP2C19 substrates can result in reduce exposure to those drugs.

Counsel about hazards and proper use in addition to checking for signs and signs and symptoms of abuse, misuse, and habit, especially in patients at elevated threat of abuse; never exceed advised dosing frequency

diazepam raises toxicity of oliceridine by Other (see remark). Modify Therapy/Keep an eye on Carefully. Remark: Anticholinergic medicine may possibly raise chance of urinary retention and/or critical constipation, which can lead to paralytic ileus.

benzhydrocodone/acetaminophen and diazepam each improve sedation. Avoid or Use Alternate Drug. Restrict use to people for whom option treatment selections are insufficient

Steer clear of or substitute Yet another drug for these drugs when doable. Examine for loss of therapeutic influence if medication has to be coadministered. Modify dose In accordance with prescribing information and facts if essential.

Suggest equally sufferers and caregivers concerning the hazards of respiratory despair and sedation when Valium is utilised with opioids. Suggest sufferers to not travel or function large machinery till the results of concomitant use Together with the opioid have been identified (see Safeguards: Drug Interactions).

diazepam decreases amounts of acetaminophen rectal by increasing metabolism. Minimal/Significance Unfamiliar. Increased metabolism incr amounts of hepatotoxic metabolites.

diazepam will improve the degree or influence of tinidazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

What's more, a transient syndrome, generally known as "rebound sleeplessness", whereby the signs that brought about treatment method with temazepam to start with recur in an Improved kind, may possibly come about on withdrawal more info of temazepam treatment thirteen.

crizotinib will increase levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Dose reduction may be essential for coadministered prescription drugs that are predominantly metabolized by CYP3A.

enzalutamide will decrease the extent or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

diazepam will enhance the stage or influence of tazemetostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

griseofulvin will lower the extent or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.